LEGend Lecture Cycle: Unravelling the secrets of healthy ageing by studying the genetic make-up of long-lived individuals

Joris Deelen, PhD Group Leader, Research Group Deelen2022

We invite you to the lecture of Joris Deelen on 13 February at 12pm in room P-05-34.


Advancing age is the major risk factor for many serious illnesses, including cardiovascular disease and dementia. However, individuals that reach an exceptional old age often seem to escape or delay age-related diseases, and part of this trait seems to be encoded in their genome. We, and others, previously performed several large genome-wide association studies (GWAS) to identify genetic variants involved in longevity [...]


LEGend Researchers Start Dementia and Glympathics Imaging Study: WHIMAS


Top: The ultra high-field 7 Tesla MRI scanner at the LUMC is used in the study — Credits C.J. Gorter MRI Center

A new study on brain imaging by LEGend researchers, the WHIMAS study, has recently started data collection from memory clinic patients at the LUMC. The aim is to study novel cerebrovascular correlates of cognitive impairment and dementia on brain scans.

Dementia is a severe multifactorial, age-related disease resulting in memory loss and cognitive decline. It is often associated [...]


LEGend Lecture Cycle: Longevity-enriched families–How did they succeed?


We invite you to a LEGend lecture of Professor Kaare Christensen on 21 February, 16:00 hrs in lecture hall 5 at the LUMC. Professor Christensen dedicated his career to ageing research in the Danish Twin Registry and Familial Longevity studies. He is a wonderful speaker and a very nice person to talk to, so come and visit his lecture entitled: Longevity-enriched families. How did they succeed?

Bio sketch

Kaare Christensen (born June 20, 1959) is a Danish epidemiologist and [...]


PhD defense: Nicolien van Vliet – thyroid and ageing

On January 25th 2023 at 13:45 hrs, Nicolien van Vliet will defend her PhD thesis titled “Is thyroid status a common denominator of age-related disease?”. You can join in person at the Academiegebouw in Leiden, or via the livestream.


UNC-ZH symposium (Dutch only)


On March 23th the yearly UNC-ZH Symposium will take place in the LUMC Burumazaal from 10.00 AM to 5.00 PM. This year’s theme is “Magie van Zorgtechnologie” and the symposium is accessible for all healthcare professionals of UNC-ZH member organisation, including the LUMC. The symposium will be in Dutch. See the program in the infographic below or on the website: unc-zh.nl. Register now by clicking the link under “Event summary” below.



New website UNC-ZH


The University Network for the Care Sector South-Holland (UNC-ZH) has a new website, which is currently operational, but still under construction. For now it is only in Dutch, but the English webpages will follow soon. We will keep you posted regarding our latests research on elderly care via:





PhD Defense: Laura Bavelaar – mySupport study

Profielfoto Laura Bavelaar

Laura Bavelaar will defend her thesis “Thinking Ahead – Supporting family caregivers of nursing home residents with dementia in advance care planning” on 28th of February at 10.00 AM. You can join in person at the Academiegebouw in Leiden, or via the livestream.


Review Uncovers Associations Between Sleep Disruption and Gut Microbiome Changes


When we sleep poorly, we immediately realize how much it affects our mood. But research suggests that poor sleep is also linked to biological changes in our gut health.

The systematic review recently published thoroughly analyzed all trials and studies associating certain bacterial profiles with poor sleep. In essence, poor sleep is associated with an inflammatory bacterial profile. Given the interest in naturally-occurring muscle mass loss due to ageing – termed sarcopenia -, mechanism through which these inflammatory gut bacteria [...]