LUMC Research Directorate: New Dutch research project grants available in 2023-24

The Research Directorate of the LUMC has sought out new grants for funding opportunities in medical research in the coming year(s). This is of interest to any researchers looking for funding to start new (large-scale) projects. Included are grants from two large funding bodies, KWF Kankerbestrijding and NWO. The funding programmes and calls can be summarized as follows:


KWF offers a Consortium project with flexible funding and different modules. The deadline is unknown at this time. [...]


LUMC study finds surprising connection between brain stem changes and cerebral small vessel disease in Alzheimer’s patients

A new study by dr. Whitney Freeze and others looked at the relationship between changes in cerebral small vessel disease and a part of the brain stem called the locus coeruleus (LC). Cerebral small vessel disease is an umbrella term for conditions affecting the brain’s blood vessels such as cerebral amyloid angiopathy and atheriolosclerosis, as both can damage small arteries. These vascular pathologies can contribute to Alzheimer’s dementia.

The researchers used brain tissue from deceased individuals who were enrolled in [...]


LUMC and Erasmus MC researchers find new patterns of brain iron accumulation in frontotemporal dementia

Louise van der Weerd, Boyd Kenkhuis and others published a paper with Erasmus MC on iron accumulation in patients with frontotemporal lobe dementia. Neuroinflammation has been implicated in frontotemporal lobar degeneration (FTLD) pathophysiology, including in genetic forms with microtubule-associated protein tau (MAPT) mutations (FTLD-MAPT) or chromosome 9 open reading frame 72 (C9orf72) repeat expansions (FTLD-C9orf72). Both DNA mutations are associated with eventual brain cell death, thereby mediating a strong decline in brain volume in the frontal and temporal areas of [...]


300k BrightFocus grant awarded to Louise van der Weerd of the LUMC to investigate brain iron spread and inflammation in Alzheimer’s disease

LUMC investigator, dr. Louise van der Weerd, has received a 300.000 euro grant from the BrightFocus Foundation for a new research project on the histopathology of Alzheimer’s dementia. In this project, van der Weerd and her group aim to do a comprehensive analysis of the histological spreading pattern of iron in the cortex of patients with varying degrees of Alzheimer’s pathology.

Amyloid and hyperphosphorylated tau are the hallmarks of Alzheimer’s Disease, and follow a specific distribution pattern, which was described [...]


TENT study on chemotherapy in elderly patients presented at annual Verenso conference


This month, PhD student Joosje Baltussen presented preliminary data on quality of life and physical functioning in older patients treated with chemotherapy at the annual Verenso conference: the Dutch Association of Elderly Care Physicians. The conference took place in Den Bosch.

The data presented are part of the Triage of Elderly Needing Treatment (TENT) study, a large multicenter prospective study from the Leiden-region that includes older patients who require intensive treatment, such as chemotherapy. Joosje and her team investigated the [...]


KWF grant for trial to investigate dose-reduced chemotherapy in older patients


Upfront dose reduction of chemotherapy in older patients with metastatic colorectal cancer may reduce the number of severe side effects of chemotherapy and thus improve quality of life. Dr. Nienke de Glas and her team have received funding from the Dutch Cancer Society (KWF) to investigate dose-reduced chemotherapy in a randomized trial that will be enrolled in 40 Dutch hospitals.

In the Netherlands, more than half of the patients diagnosed with metastatic colorectal cancer are 70 years or older. [...]


Annual meeting Dutch Society for Research on Ageing (DuSRA)

Dusra (3)

We are pleased to announce the annual meeting of The Dutch Society for Research on Ageing (DuSRA) that will take place from 15 June till 16 June 2023 at the University Medical Center, Groningen, The Netherlands.

Confirmed keynote speakers are:

Mihai Netea (Radboud UMC, Nijmegen), Collin Ewald (ETH Zürich), and Ron Jachimowicz, (MPI Biology of Aging, Cologne).

Abstract submission deadline May 15th 2023

To try to improve structural support for aging research in the Netherlands for the coming years, the [...]


ERACE Study started on the intergenerational transmission of parental adverse childhood experiences


Researchers at Health Campus the Hague (LUMC) and the Juliana Children’s Hospital (the Hague), have started a new study on the intergenerational transmission of parental adverse childhood experiences (ACEs). These are potentially traumatic events that occur during childhood. ACEs can have long-lasting negative consequences. Recent literature even suggests that parents can transmit their ACEs onto their children. Children born to parents with ACEs have a higher risk of being born prematurely or small for gestational age. The mechanisms of intergenerational [...]


LEGend Lecture Cycle: Two decades of LUMC Lifecourse ageing research–the Leiden Longevity Study cohort


You are all invited to join our next exciting Lecture Cycle session on the 19th of June from 17.00-18.00 in J-01-116 (LUMC building 1), route 554, or via Microsoft Teams. In the session we will discuss the Leiden Longevity Study (LLS), one of the most original and deeply phenotyped LUMC cohort studies with over 20 years of follow up aimed at establishing determinants of health, (co)morbidity, mortality and longevity. Numerous publications and collaborations have resulted from this study.

This [...]


Ed Maartense Symposium: kankerbehandeling bij ouderen (Dutch only)


Ed Maartense Symposium

In het Reinier de Graaf Gasthuis is sedert jaar en dag aandacht voor de behandeling van oncologische patiënten op oudere leeftijd en de specifieke zorg die past bij hun behandeling. Dr. Ed Maartense was een van de pioniers in dit aandachtsgebied. Meer dan 30 jaar heeft hij zich als internist hematoloog en oncoloog toegelegd op de behandeling van oudere patiënten met kanker en zeer veel jongere collegae opgeleid in de geriatrische oncologie. Ter nagedachtenis aan hem [...]