Abstract

Plasma levels of lipoprotein(a) – Lp(a) – are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.

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TitleTwo-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels.
DateAugust 1st, 2003
Issue nameTwin research : the official journal of the International Society for Twin Studies
Issue numberv6.4:322-4
DOI10.1375/136905203322296692
PubMed14511440
AuthorsBeekman M, Heijmans BT, Martin NG, Whitfield JB, Pedersen NL, DeFaire U, Snieder H, Lakenberg N, de Knijff P, Frants RR, van Ommen GJ, Kluft C, Vogler GP, Slagboom PE & Boomsma DI
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