Abstract
Increased signaling of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) elicits apoptosis of skeletal muscle cells in various animal models. Within a population-based prospective follow up study of elderly people aged 85 years we show that a high innate production capacity of TNF-alpha precedes a steeper decline in muscle strength over time.
Overview publication
| Title | High innate production capacity of tumor necrosis factor-alpha and decline of handgrip strength in old age. |
| Date | September 1st, 2007 |
| Issue name | Mechanisms of ageing and development |
| Issue number | v128.9:517-21 |
| DOI | 10.1016/j.mad.2007.07.001 |
| PubMed | 17714763 |
| Authors | |
| Read | Read publication |