Abstract
It has been suggested in the literature that atherosclerosis is a common causal pathway of cognitive impairment and late-onset depression, which may explain their co-occurrence in old age. In both the ‘Leiden 85-plus Study’ and the literature, strong evidence is found for a causal relationship between atherosclerosis and cognitive impairment, but there is less evidence for a causal relationship between atherosclerosis and late-onset depression. In the ‘Leiden 85-plus Study’, cognitive impairment was a risk factor for the development of late-onset depression, but depression in old age did not predict cognitive decline. This means that the prevention of atherosclerosis might prevent cognitive impairment and hence late-onset depression in old age.
Overview publication
Title | [The relationship between atherosclerosis, cognitive impairment, and depression in old age]. |
Date | October 21st, 2006 |
Issue name | Nederlands tijdschrift voor geneeskunde |
Issue number | v150.42:2307-11 |
PubMed | 17089547 |
Authors | |
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