Background
Despite its negative consequences, little is known about the natural history of depression in the oldest old.
Aims
To study the incidence, course and predictors of depression in the general population of the oldest old.
Method
The Leiden 85-plus Study is a prospective population-based study of 500 people from their 85th to their 89th birthdays. Depressive symptoms were annually assessed with the 15-item Geriatric Depression Scale, using a cut-off of 4 points.
Results
During a mean follow-up of 3.9 years, the annual risk for the emergence of depression was 6.8%. Poor daily functioning and institutionalisation predicted depression. Among the 77 participants with depression at baseline (prevalence 15%) the annual remission rate was ony 14%. In more than half of the participants with a remission of depression, we observed a relapse of depression during follow-up. No predictors of remission could be identified.
Conclusions
Among the oldest old, depression is frequent and highly persistent. More active case-finding and treatment would be potentially rewarding.
Overview publication
Title | Natural history of depression in the oldest old: population-based prospective study. |
Date | January 1st, 2006 |
Issue name | The British journal of psychiatry : the journal of mental science |
Issue number | v188:65-9 |
DOI | 10.1192/bjp.188.1.65 |
PubMed | 16388072 |
Authors | |
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