Abstract
Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed.
Overview publication
Title | Methylation status of cKi-ras and MHC genes in rat pituitary glands during aging and tumorigenesis. |
Date | June 1st, 1991 |
Issue name | Aging (Milan, Italy) |
Issue number | v3.2:141-6 |
DOI | 10.1007/BF03323991 |
PubMed | 1911902 |
Authors | |
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