Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.
Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.
Overview publication
Title | MARK-AGE biomarkers of ageing. |
Date | November 1st, 2015 |
Issue name | Mechanisms of ageing and development |
Issue number | v151:2-12 |
DOI | 10.1016/j.mad.2015.03.006 |
PubMed | 25818235 |
Authors | |
Keywords | Ageing biomarkers, Human studies, MARK-AGE |
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