Aims
It has been suggested that in patients with type 2 diabetes mellitus (T2DM), brain atrophy is most pronounced in the hippocampus, but this has not been investigated systematically. The present pooled analysis of three studies examined if hippocampal atrophy is more prominent than global brain atrophy in patients with T2DM relative to controls.
Methods
Data were derived from a cohort study of patients with vascular disease (SMART-Medea (T2DM=120; no T2DM=502)), and from two case-control studies (UDES1 (T2DM=61; controls=30) and UDES2 (T2DM=54; controls=53)). In SMART-Medea and UDES1, hippocampal volume was obtained by manual tracing on 1.5 Tesla (T) MRI scans. Total brain and intracranial volume (ICV) were determined by an automated segmentation method. In UDES2, hippocampal and total brain volume were determined by FreeSurfer and ICV by manual segmentation on 3 T MRI scans.
Results
The pooled analyses, adjusted for age and sex, showed a significant negative relation between T2DM and total brain-to-ICV ratio (standardized mean difference=-1.24%, 95% CI: -1.63; -0.86), but not between T2DM and hippocampal-to-ICV ratio (0.00%, 95% CI: -0.01; 0.00) or between T2DM and hippocampal-to-total brain volume ratio (0.01%, 95% CI: -0.01; 0.02). In patients with T2DM no associations were found between brain volume measures and HbA1c or memory.
Conclusion
Patients with T2DM had greater brain atrophy but not hippocampal atrophy, compared to controls. These findings do not support specific vulnerability of the hippocampus in patients with T2DM.
Copyright © 2014 Elsevier B.V. All rights reserved.
Overview publication
Title | Global brain atrophy but not hippocampal atrophy is related to type 2 diabetes. |
Date | September 15th, 2014 |
Issue name | Journal of the neurological sciences |
Issue number | v344.1-2:32-6 |
DOI | 10.1016/j.jns.2014.06.008 |
PubMed | 24958596 |
Authors | |
Info | Algra A, Doevendans PA, van der Graaf Y, Grobbee DE, Rutten GE, Kappelle LJ, Mali WP, Moll FL, Visseren FL, Algra A, van den Berg E, Biessels GJ, Brands AM, Breedijk MA, de Bresser J, Brundel M, van Gijn J, Gispen WH, van der Grond J, de Haan EH, van Huffelen AC, Jongen C, Kappelle LJ, Kessels RP, Mali WP, Manschot SM, Pluim JP, Reijmer YD, Rutten GE, Tiehuis AM, de Valk HW, Viergever MA, Wisse LE |
Keywords | Atrophy, Brain, Hippocampus, MRI, Type 2 diabetes |
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